Fresh analysis indicates that patients who discontinue new GLP-1 drugs like Wegovy and Mounjaro can put back on lost weight far faster than those who stop traditional diet and exercise programs.
Findings released in a leading medical journal points out that while obese people frequently drop a large proportion of their total mass while undergoing treatment, the mass returns at an average rate of nearly a kilo each month after stopping.
"Individuals using such medications should be cognizant of the potential of rapid rebound weight gain when the therapy concludes," cautioned lead investigator Dr. Susan Jebb.
That rate of regain suggests a return to starting weight within about one and a half years.
Analyzing Therapies
The research, which examined dozens of trials involving over 9,000 of patients, contrasted the effects of the injectable medications with older methods.
Researchers point out that individuals who lose weight through lifestyle changes alone typically have a slower creep back—around 0.1 kg a month—once they finish.
Understanding the Fast Rebound
Doctors suggest the mode of action of the injections explains the heightened regain.
GLP-1 drugs copy a natural hormone called GLP-1, which moderates feelings of fullness.
"Sustained high doses of the hormone levels far above than the body's typical production may cause the system to produce less of its own natural GLP-1, and may also reduce sensitivity to its effects," explained Dr. Adam Collins, a dietetics expert.
"Stopping of this GLP-1 'fix' means appetite is uncontrolled, making excessive eating a significant risk."
An Ongoing Issue?
Health authorities advise the injections for people with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
Many experts say that, considering the high risk of weight regain, the treatment should be considered long-term.
This perspective is echoed by drug manufacturers, who state that the findings "emphasize the long-term nature of obesity," similar to managing conditions like hypertension.
User Accounts
People who have come off the medication explain a powerful resurgence of hunger.
"It felt as if a switch flipping and you're instantly ravenous," said one woman.
This difficulty is worsened if individuals have not developed lasting lifestyle or habit changes during treatment.
Significant Interest
Survey data suggest that millions of people in the UK have tried weight-loss jabs in the last 12 months, with interest continuing to grow.
- Use is greater among females compared to males.
- The middle-aged age group shows the highest usage rates.
- Many obtain the medications through private prescriptions rather than public health services.
In conclusion, experts caution that while the jabs are effective tools for weight loss, they are not a permanent cure and long-term success hinges on integrated lifestyle changes.
