RAF Typhoon FGR4s have conducted a mission with French aircraft in a coordinated attack targeting an subterranean weapons facility in Syria operated by the IS group, according to the British defence ministry.
The facility, located using reconnaissance, was believed to be storing arms and explosives, the release indicated, and was located in mountainous terrain just to the north of Palmyra in central Syria.
"The RAF jets employed laser-guided Paveway IV weapons to target a series of entry passages providing entry to the depot... initial indications suggest the target was engaged successfully," officials stated.
There was no evidence of any civilian casualties in the operation on Saturday evening and all the aircraft returned safely, the MoD added.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as the so-called Islamic State - established extremist governance over large swathes of Iraq and Syria until 2019.
"This strike shows British leadership, and resolve to stand shoulder to shoulder with our partners, to stamp out any re-emergence of Daesh and their violent and radical beliefs in the area," Britain's Defence Chief the Defence Secretary stated.
RAF aircraft have performed overwatch operations over Syrian airspace to "deter any attempted comeback" of Islamic State following its routing at the Baghuz confrontation in 2019, the ministry said.
"I want to thank every member of our armed forces who took part in this strike for their professionalism and their courage," he said. "They were among a great many UK service members deployed over the holidays. This mission, to take out dangerous terrorists who endanger our way of life, demonstrates how our armed forces are always on standby, continuously, protecting the UK within its borders and powerful internationally."
During December, the American forces executed what it termed a "massive strike" against Islamic State objectives in Syria, subsequent to an ambush killed two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations reports Islamic State still maintains roughly 5-7 thousand fighters in Syria and Iraq.